Age-adjustment of the D-dimer cut-off value to improve the exclusion of thromboembolic events in older patients
نویسنده
چکیده
In 2010, Douma et al introduced a formula to adjust D-dimer cut-off values for age in outpatients >50 years: Age × 0.01 mg/L. Application of this approach in different retrospective cohorts confirmed that age adjustment increases specificity while hardly affecting sensitivity. Reducing the false positive results, the ageadjusted D-dimer cut-off point raises the proportion of older patients in whom an acute thromboembolic event can be safely excluded.
منابع مشابه
Validation of two age dependent D-dimer cut-off values for exclusion of deep vein thrombosis in suspected elderly patients in primary care: retrospective, cross sectional, diagnostic analysis OPEN ACCESS
Objective To determine whether the use of age adapted D-dimer cut-off values can be translated to primary care patients who are suspected of deep vein thrombosis. Design Retrospective, cross sectional diagnostic study. Setting 110 primary care doctors affiliated with three hospitals in the Netherlands. Participants 1374 consecutive patients (936 (68.1%) aged >50 years) with clinically suspected...
متن کاملPotential of an age adjusted D-dimer cut-off value to improve the exclusion of pulmonary embolism in older patients: a retrospective analysis of three large cohorts
OBJECTIVES In older patients, the the D-dimer test for pulmonary embolism has reduced specificity and is therefore less useful. In this study a new, age dependent cut-off value for the test was devised and its usefulness with older patients assessed. DESIGN Retrospective multicentre cohort study. SETTING General and teaching hospitals in Belgium, France, the Netherlands, and Switzerland. Pa...
متن کاملValidation of two age dependent D-dimer cut-off values for exclusion of deep vein thrombosis in suspected elderly patients in primary care: retrospective, cross sectional, diagnostic analysis
OBJECTIVE To determine whether the use of age adapted D-dimer cut-off values can be translated to primary care patients who are suspected of deep vein thrombosis. DESIGN Retrospective, cross sectional diagnostic study. SETTING 110 primary care doctors affiliated with three hospitals in the Netherlands. PARTICIPANTS 1374 consecutive patients (936 (68.1%) aged >50 years) with clinically sus...
متن کاملUsing an age-dependent D-dimer cut-off value increases the number of older patients in whom deep vein thrombosis can be safely excluded.
BACKGROUND D-dimer testing to rule out deep vein thrombosis is less useful in older patients because of a lower specificity. An age-adjusted D-dimer cut-off value increased the proportion of older patients (>50 years) in whom pulmonary embolism could be excluded. We retrospectively validated the efficacy of this cut-off combined with clinical probability for the exclusion of deep vein thrombosi...
متن کاملComparison of five D-dimer reagents and application of an age-adjusted cut-off for the diagnosis of venous thromboembolism in emergency department.
There is still a considerable uncertainty concerning D-dimer cut-off values used in exclusion of venous thromboembolic (venous thromboembolism, VTE) disease, especially among the elderly patients. The objectives were to compare five different D-dimer reagents in the daily practice of an emergency department and to test retrospectively the performances of an age-adjusted cut-off. A total of 473 ...
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